Gamma-hydroxybutyrate (GHB) is a central nervous system depressant that has gained attention over recent years for its illicit recreational uses. Originally synthesized as an anesthetic, it has found its way into various subcultures primarily as a party drug.

GHB operates on the brain by increasing the levels of a neurotransmitter called gamma-aminobutyric acid (GABA). This neurotransmitter is responsible for promoting a sense of calm and relaxation, not unlike with addictive opioids. However, GHB possesses characteristics that can quickly transition the experience from blissful to dangerous.

What Makes a Drug a Party Drug?

A party drug is typically characterized by its ability to enhance moods, intensify sensory perceptions, and diminish social inhibitions. Various substances fall into this category, ranging from stimulants like ecstasy to depressants like GHB.

When evaluating what makes a drug a party drug, factors such as availability, legality, and societal acceptance play crucial roles. GHB, for instance, has been embraced in some nightlife scenes due to its psychoactive effects that enhance social interaction and the enjoyment of music and dance.

However, while party drugs may offer temporary pleasure or escape, they frequently come with significant risks of health complications and potential legal repercussions. The euphoric effects of these substances can lead to a false sense of security, encouraging users to engage in risky behaviors, such as excessive drinking or unprotected sex, which can have long-lasting consequences on both physical and mental health.

The culture surrounding party drugs can often perpetuate a cycle of use that can be difficult to break. Many individuals may feel pressure to conform to social norms that glorify drug use as a means of enhancing the nightlife experience. This normalization can lead to increased experimentation with various substances, often without a full understanding of their effects or the potential for addiction. As a result, the allure of party drugs can overshadow the critical conversations about safety, consent, and the importance of making informed choices in social settings.

Why is GHB Called the Date Rape Drug?

GHB is commonly known as the “date rape drug” due to its unfortunate association with cases of drug-facilitated sexual assault. Some perpetrators take advantage of GHB’s colorless, odorless, and tasteless properties by secretly administering the substance to unsuspecting victims, making it exceedingly difficult to detect. The substance can induce sedation and amnesia, in some cases leading individuals to be unable to recall events that occurred while under its influence.

The alkaloid compounds in GHB make it particularly dangerous when mixed with alcohol, in that it enhances the drug’s sedative effects. In America, this has led to a common culture of “covering your drink” or “watching your drink” in settings like pubs and parties. Young people just starting to drink legally are often taught to never imbibe in a beverage that isn’t theirs, and to hold on to their drink the whole night. Bars frequently display posters of codes and/or signals that people can say to bar staff to covertly ask for help if they’ve been drugged or feel unsafe.

Short- and Long-Term Effects of Using GHB

Young woman holding head the day after trying GHB

The short-term effects of GHB can manifest within 15 to 30 minutes of ingestion. Symptoms often include intoxication, dizziness, decreased inhibition, and euphoria. This can sometimes lead to adverse effects like nausea, confusion, hallucinations, and respiratory depression.

The intensity of these effects can vary widely depending on factors, such as dosage, individual tolerance, and whether it is mixed with other substances. As users seek heightened effects, there is a danger of consuming more than the body can tolerate, which increases the risk of blackouts or overdose.

Long-term use of GHB can result in more persistent effects on the body and mind. Chronic use may lead to a physical dependence on the drug, characterized by withdrawal symptoms such as insomnia, anxiety symptoms, and tremors when not consumed.

Additionally, long-term users have reported significant cognitive impairments, characterized by difficulties with memory, concentration, and decision-making abilities. These adverse effects can hinder one’s ability to maintain professional and personal relationships, leading to isolation and mental health struggles. The physiological toll of prolonged GHB use can manifest in other ways and can potentially complicate existing health conditions. The social stigma surrounding substance use can also prevent individuals from seeking help, perpetuating a cycle of dependency and further psychological distress.

The Dangers of Using GHB

The dangers of using GHB extend beyond its immediate intoxicating effects. One significant risk is the potential for overdose, which can lead to severe medical emergencies, including loss of consciousness, respiratory failure, and even death. The narrow therapeutic window of GHB means that the difference between a recreational dose and an overdose can be dangerously slight.

Furthermore, the illegal manufacture and distribution of GHB often lead to inconsistent dosing and purity of products. This lack of regulation can result in contaminated substances that may contain harmful additives, increasing the risk of adverse effects.

In addition to the physical dangers, GHB use can also have profound psychological effects. Users may experience heightened feelings of euphoria initially, but this can quickly give way to confusion, anxiety, and paranoia. Long-term use can lead to dependence, with withdrawal symptoms that can be both uncomfortable and dangerous, including insomnia, tremors, and in severe cases, seizures. The psychological toll of GHB can disrupt personal relationships and lead to social isolation, as users may prioritize substance use over their responsibilities and connections to others.

The combination of GHB with other substances, such as alcohol or stimulants, can significantly increase the risk of overdose and other harmful effects. This polydrug use can impair judgment and lead to risky behaviors, including unprotected sex or driving under the influence.

Signs of Drug Addiction

Recognizing the signs of drug addiction is critical for understanding when someone might need assistance. Common indicators of GHB addiction include:

  • An intense focus on obtaining and using the drug
  • Withdrawal symptoms when not using
  • Neglecting responsibilities at work or home
  • Prioritizing substance use over essential life tasks, such as maintaining relationships or fulfilling job obligations
  • Secrecy
  • Mood swings
  • Social withdrawal
  • Increased tolerance to the drug’s effects
  • Experiencing cravings or urges to use GHB
  • Loss of control over drug intake
  • Continuing to use despite negative consequences
  • Weight fluctuations
  • Poor hygiene
  • Unusual sleep patterns

Individuals may become increasingly isolated, distancing themselves from friends and family who do not share their drug-using habits. This social withdrawal can exacerbate feelings of loneliness and despair, creating a vicious cycle that can be difficult to escape. Individuals may also prioritize drug use over personal safety or well-being. This could manifest in dangerous situations, such as driving under the influence or mixing substances. These can have severe physical and legal repercussions.

The psychological impact of GHB addiction can be profound. Users may experience feelings of heightened anxiety, symptoms of depression, or paranoia. This can further complicate their ability to seek help. The euphoric effects of GHB can create a powerful cycle of addiction, making it difficult for individuals to envision a life without the substance. As tolerance builds, users often find themselves needing larger doses to achieve the same effects, which can lead to an increased risk of overdose and other health issues.

It is essential for loved ones to approach the situation with compassion and understanding, as the stigma surrounding drug addiction can often prevent individuals from seeking the help they desperately need. Open and honest conversations about the observed behaviors can be a first step toward encouraging someone to seek professional assistance.

What is GHB?

Home > Drug Addiction > What is GHB?

Gamma-hydroxybutyrate (GHB) is a central nervous system depressant that has gained attention over recent years for its illicit recreational uses. Originally synthesized as an anesthetic, it has found its way into various subcultures primarily as a party drug.

GHB operates on the brain by increasing the levels of a neurotransmitter called gamma-aminobutyric acid (GABA). This neurotransmitter is responsible for promoting a sense of calm and relaxation, not unlike with addictive opioids. However, GHB possesses characteristics that can quickly transition the experience from blissful to dangerous.

What Makes a Drug a Party Drug?

A party drug is typically characterized by its ability to enhance moods, intensify sensory perceptions, and diminish social inhibitions. Various substances fall into this category, ranging from stimulants like ecstasy to depressants like GHB.

When evaluating what makes a drug a party drug, factors such as availability, legality, and societal acceptance play crucial roles. GHB, for instance, has been embraced in some nightlife scenes due to its psychoactive effects that enhance social interaction and the enjoyment of music and dance.

However, while party drugs may offer temporary pleasure or escape, they frequently come with significant risks of health complications and potential legal repercussions. The euphoric effects of these substances can lead to a false sense of security, encouraging users to engage in risky behaviors, such as excessive drinking or unprotected sex, which can have long-lasting consequences on both physical and mental health.

The culture surrounding party drugs can often perpetuate a cycle of use that can be difficult to break. Many individuals may feel pressure to conform to social norms that glorify drug use as a means of enhancing the nightlife experience. This normalization can lead to increased experimentation with various substances, often without a full understanding of their effects or the potential for addiction. As a result, the allure of party drugs can overshadow the critical conversations about safety, consent, and the importance of making informed choices in social settings.

Why is GHB Called the Date Rape Drug?

GHB is commonly known as the "date rape drug" due to its unfortunate association with cases of drug-facilitated sexual assault. Some perpetrators take advantage of GHB's colorless, odorless, and tasteless properties by secretly administering the substance to unsuspecting victims, making it exceedingly difficult to detect. The substance can induce sedation and amnesia, in some cases leading individuals to be unable to recall events that occurred while under its influence.

The alkaloid compounds in GHB make it particularly dangerous when mixed with alcohol, in that it enhances the drug's sedative effects. In America, this has led to a common culture of "covering your drink" or "watching your drink" in settings like pubs and parties. Young people just starting to drink legally are often taught to never imbibe in a beverage that isn't theirs, and to hold on to their drink the whole night. Bars frequently display posters of codes and/or signals that people can say to bar staff to covertly ask for help if they've been drugged or feel unsafe.

Short- and Long-Term Effects of Using GHB

Young woman holding head the day after trying GHB

The short-term effects of GHB can manifest within 15 to 30 minutes of ingestion. Symptoms often include intoxication, dizziness, decreased inhibition, and euphoria. This can sometimes lead to adverse effects like nausea, confusion, hallucinations, and respiratory depression.

The intensity of these effects can vary widely depending on factors, such as dosage, individual tolerance, and whether it is mixed with other substances. As users seek heightened effects, there is a danger of consuming more than the body can tolerate, which increases the risk of blackouts or overdose.

Long-term use of GHB can result in more persistent effects on the body and mind. Chronic use may lead to a physical dependence on the drug, characterized by withdrawal symptoms such as insomnia, anxiety symptoms, and tremors when not consumed.

Additionally, long-term users have reported significant cognitive impairments, characterized by difficulties with memory, concentration, and decision-making abilities. These adverse effects can hinder one’s ability to maintain professional and personal relationships, leading to isolation and mental health struggles. The physiological toll of prolonged GHB use can manifest in other ways and can potentially complicate existing health conditions. The social stigma surrounding substance use can also prevent individuals from seeking help, perpetuating a cycle of dependency and further psychological distress.

The Dangers of Using GHB

The dangers of using GHB extend beyond its immediate intoxicating effects. One significant risk is the potential for overdose, which can lead to severe medical emergencies, including loss of consciousness, respiratory failure, and even death. The narrow therapeutic window of GHB means that the difference between a recreational dose and an overdose can be dangerously slight.

Furthermore, the illegal manufacture and distribution of GHB often lead to inconsistent dosing and purity of products. This lack of regulation can result in contaminated substances that may contain harmful additives, increasing the risk of adverse effects.

In addition to the physical dangers, GHB use can also have profound psychological effects. Users may experience heightened feelings of euphoria initially, but this can quickly give way to confusion, anxiety, and paranoia. Long-term use can lead to dependence, with withdrawal symptoms that can be both uncomfortable and dangerous, including insomnia, tremors, and in severe cases, seizures. The psychological toll of GHB can disrupt personal relationships and lead to social isolation, as users may prioritize substance use over their responsibilities and connections to others.

The combination of GHB with other substances, such as alcohol or stimulants, can significantly increase the risk of overdose and other harmful effects. This polydrug use can impair judgment and lead to risky behaviors, including unprotected sex or driving under the influence.

Signs of Drug Addiction

Recognizing the signs of drug addiction is critical for understanding when someone might need assistance. Common indicators of GHB addiction include:

  • An intense focus on obtaining and using the drug
  • Withdrawal symptoms when not using
  • Neglecting responsibilities at work or home
  • Prioritizing substance use over essential life tasks, such as maintaining relationships or fulfilling job obligations
  • Secrecy
  • Mood swings
  • Social withdrawal
  • Increased tolerance to the drug's effects
  • Experiencing cravings or urges to use GHB
  • Loss of control over drug intake
  • Continuing to use despite negative consequences
  • Weight fluctuations
  • Poor hygiene
  • Unusual sleep patterns

Individuals may become increasingly isolated, distancing themselves from friends and family who do not share their drug-using habits. This social withdrawal can exacerbate feelings of loneliness and despair, creating a vicious cycle that can be difficult to escape. Individuals may also prioritize drug use over personal safety or well-being. This could manifest in dangerous situations, such as driving under the influence or mixing substances. These can have severe physical and legal repercussions.

The psychological impact of GHB addiction can be profound. Users may experience feelings of heightened anxiety, symptoms of depression, or paranoia. This can further complicate their ability to seek help. The euphoric effects of GHB can create a powerful cycle of addiction, making it difficult for individuals to envision a life without the substance. As tolerance builds, users often find themselves needing larger doses to achieve the same effects, which can lead to an increased risk of overdose and other health issues.

It is essential for loved ones to approach the situation with compassion and understanding, as the stigma surrounding drug addiction can often prevent individuals from seeking the help they desperately need. Open and honest conversations about the observed behaviors can be a first step toward encouraging someone to seek professional assistance.

Dr. Carlos Satulovsky

Dr. Carlos Satulovsky ( Medical Director )
Dr. Carlos Satulovsky is a board-certified psychiatrist and has over 30 years of experience in the medical field. He graduated from Facultad De Ciencias Medicas/Universidad Nacional. He is affiliated with medical facilities North Shore Medical Center.
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